Paper on comparing networks of two groups of patients with MDD

Our paper on comparing networks of two groups of patients with Major Depressive Disorder was published in JAMA Psychiatry (PDF).

In this paper, we investigated the association between baseline network structure of depression symptoms and the course of depression. We compared the baseline network structure of persisters (defined as patients with MDD at baseline and depressive symptomatology at 2-year follow-up) and remitters (patients with MDD at baseline without depressive symptomatology at 2-year follow-up). To compare network structures we used the first statistical test that directly compares connectivity of two networks (Network Comparison Test; NCT). While both groups have similar symptomatology at baseline, persisters have a more densely connected network compared to remitters. More specific symptom associations seem to be an important determinant of persistence of depression.

A Dutch newspaper (NRC Handelsblad, November 21st, 2015) published a piece about this paper (Link).